Compounded Semaglutide + Glycine Injections
Price range: $125.00 through $225.00
Initial charge of $34 for consult, price of medication(s) charged upon consult approval.
Support your metabolic wellness with once-weekly, clinician-guided GLP-1 therapy designed to complement—not replace—your nutrition, movement, and lifestyle plan.
Compounded semaglutide with glycine is a prescription medication formulated to support weight management and metabolic health by targeting hunger, satiety, and blood-sugar regulation—while pairing semaglutide with the amino acid glycine.
Semaglutide is a GLP-1 receptor agonist that helps regulate appetite and blood sugar. Glycine is a naturally occurring amino acid that supports overall wellness, including tissue repair, metabolic processes, and healthy sleep patterns. Together, they are used as part of a comprehensive, clinician-directed approach to metabolic health.
This once-weekly, at-home injectable is personalized to your needs and designed to support sustainable lifestyle changes—never as a stand-alone “quick fix.”
Important Note: Compounded medications are prepared by licensed U.S. compounding pharmacies and are not reviewed or approved by the FDA. Your Wellcore provider will determine if compounded semaglutide with glycine is appropriate based on your clinical evaluation.
This therapy combines GLP-1–based appetite regulation with amino-acid support:
Semaglutide (GLP-1 receptor agonist):
- Helps regulate hunger and satiety by acting on GLP-1 receptors
- Slows gastric emptying, helping you feel fuller for longer
- Supports blood-sugar control and metabolic balance
- Helps reduce cravings and overall caloric intake over time
Glycine (amino acid):
- Supports healthy metabolic and cellular processes
- Plays a role in tissue repair, muscle recovery, and collagen synthesis
- Helps support restorative sleep and overall well-being as part of a healthy lifestyle
Working together, semaglutide and glycine are designed to support body-weight management and metabolic wellness within a structured, clinician-guided plan.
Compounded semaglutide with glycine offers a flexible, integrated approach to metabolic health:
- Once-weekly, at-home injections – Subcutaneous injections you administer yourself; no routine office visits required
- Clinician-guided dosing and titration – Your provider personalizes your starting dose and adjustment schedule
- GLP-1 + amino-acid support – Pairs semaglutide with glycine to support overall wellness and recovery
- Flexible vial strengths – Compounded in a range of vial sizes to match your dosing plan and treatment stage
- Prepared by licensed U.S. compounding pharmacies – With ongoing clinical oversight from your Wellcore provider
- Integrated into a full wellness strategy – Designed to work alongside nutrition, movement, sleep, and stress-management—not replace them
Use this general guide to understand potential eligibility. Final eligibility is always determined by a Wellcore provider after a full evaluation.
| BMI | Am I Eligible?* |
| ≤ 24.9 | Not eligible |
| 25.0–26.9 | Case-by-case** |
| 27.0–29.9 | Likely eligible** |
| 30.0+ | Likely eligible** |
Compounded semaglutide with glycine may be considered for adults who:
- Are seeking medical support for weight management and metabolic health
- Have struggled to achieve or maintain weight-loss goals with lifestyle changes alone
- Are willing to commit to once-weekly injections and ongoing lifestyle optimization
- Do not have conditions that would make GLP-1 therapy unsafe
Your provider will also consider other factors—such as insulin resistance, prediabetes, blood-sugar control, cardiovascular risk, GI history, and current medications—before recommending treatment.
Your provider will design a dosing and titration plan tailored to your health profile and goals.
General guidance includes:
- Route: Subcutaneous injection (just under the skin), typically in the abdomen or thigh
- Frequency: Inject once weekly, on the same day each week, as directed
- Titration: You will usually start at a lower dose and increase gradually to support comfort and tolerability
- Consistency: Take your dose at roughly the same time each week for stable exposure
- Instructions: Every shipment includes step-by-step instructions for safe storage, handling, and self-administration
Never adjust your dose, skip titration steps, or change your schedule without consulting your provider.
Complete Treatment Package
- Multi-dose vial(s) of compounded semaglutide with glycine in your prescribed strength
- Syringes, injection needles, and alcohol swabs
- Provider-directed dosing and titration instructions
- Cold-packed, discreet shipping delivered to your home (where permitted)
- Access to Wellcore’s clinical support team for questions, progress check-ins, and side-effect guidance
Kit components may vary slightly based on your prescription and partner pharmacy.
Your Treatment Journey
Start Your Online Evaluation
Get approved by provider
Receive Your product at Home
Start treatment with provider guidance
How is semaglutide with glycine different from semaglutide with B12?
Both are GLP-1–based therapies using semaglutide to support appetite regulation, satiety, and metabolic health. In one formulation, semaglutide is paired with B12, which primarily supports cellular energy and red blood cell health. In this formulation, semaglutide is paired with glycine, an amino acid that supports tissue repair, metabolic processes, and overall wellness. Your provider can help you decide which combination aligns best with your health status and goals.
Is compounded semaglutide with glycine FDA-approved?
No. Compounded semaglutide with glycine is not reviewed or approved by the FDA. It is prepared by licensed U.S. 503A compounding pharmacies for individual patients, under a provider’s prescription. Your Wellcore provider will discuss how compounded therapy compares with FDA-approved options and whether it is appropriate for you.
When will I start to notice changes?
Experiences vary. Some people notice changes in appetite, fullness, and cravings within the first few weeks. Visible changes in weight and body composition typically occur over 1–3+ months, depending on dose, adherence, and lifestyle. Your provider will monitor your response and adjust your dosing plan as needed.
Do I still need to focus on diet and exercise?
Yes. Compounded semaglutide with glycine is meant to enhance—not replace—healthy eating, regular movement, restorative sleep, and stress-management habits. Your best, most sustainable results come from combining medication with consistent lifestyle practices.
Can I switch between different GLP-1 formulations later?
Potentially. If your needs change, your provider may consider transitioning you between GLP-1 formulations (for example, semaglutide with B12 vs. semaglutide with glycine vs. a different incretin therapy). Any switch should be planned and supervised by your provider; never change therapies on your own.
Do Not Use This Medication If You:
- Have a personal or family history of medullary thyroid carcinoma (MTC)
- Have multiple endocrine neoplasia syndrome type 2 (MEN 2)
- Are pregnant, planning to become pregnant, or breastfeeding
- Are allergic to semaglutide, glycine, or any ingredient in the formulation
Use With Caution If You:
- Have a history of pancreatitis
- Have severe gastrointestinal disease (such as gastroparesis)
- Have significant kidney or liver impairment
- Take medications that affect blood sugar, insulin, or gastric emptying
- Have complex cardiovascular or endocrine conditions
Always provide your provider with a full list of medications, supplements, and medical conditions before starting therapy.
Common Side Effects May Include:
- Nausea (most common, especially during dose escalation)
- Bloating, fullness, or mild abdominal discomfort
- Constipation or diarrhea
- Decreased appetite
- Headache or fatigue
- Mild redness, itching, or discomfort at the injection site
Side effects are often mild to moderate and may improve as your body adjusts and as your provider gradually increases your dose. Contact your provider if symptoms are severe, persistent, or concerning.
Seek immediate medical attention if you experience signs of a severe allergic reaction (hives, swelling of the face, lips, tongue, or throat, difficulty breathing), severe abdominal pain, or other alarming symptoms.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. All information is for educational purposes only and does not replace individualized medical advice from a qualified healthcare professional.
Important Information About Compounded Semaglutide with Glycine
- Compounded medications are not reviewed or approved by the FDA and do not undergo the same pre-market testing as FDA-approved drugs.
- Wellcore’s compounded semaglutide with glycine is prepared using semaglutide base and glycine by FDA-registered, U.S.-licensed 503A compounding pharmacies, where available and appropriate.
- Product availability may vary based on state regulations, clinical appropriateness, and pharmacy partners.
Wellcore does not practice medicine or provide direct medical care. All prescriptions and treatment decisions are made independently by licensed healthcare providers exercising their professional judgment. Images and product representations are for illustration only; actual packaging and supplies may differ.
*If you are interested in a prescription product, Wellcore will coordinate a telehealth consultation with a licensed medical provider who will evaluate whether you are an appropriate candidate based on your health profile and current standards of care. If approved, your prescription will be filled by one of our partner pharmacies unless you request a different pharmacy. All prescriptions are subject to provider discretion and clinical appropriateness.